IL4 - interleukin 4 Gene
Also Known as BSF1; IL-4; BCGF1; BSF-1; BCGF-1
Species: Homo sapiens
About IL4
This gene has 4 transcripts (splice variants) and 92 orthologues. Low expression observed in reference dataset.
Summary
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, Anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]
IL4 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_172348.3 | NP_758858.1 | interleukin-4 isoform 2 precursor |
| NM_000589.4 | NP_000580.1 | interleukin-4 isoform 1 precursor |
| NM_001354990.2 | NP_001341919.1 | interleukin-4 isoform 3 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables cytokine activity |
IDA
IDA: Inferred from direct assay
|
10219247 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
8266078 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| is active in extracellular space |
IDA
IDA: Inferred from direct assay
|
3279117 | GOA |
IL4 Protein Structure
IL4: Interleukin 4 (25 - 149)
- 0
- 100
- 153 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
interleukin-4 |
|
|
IL4 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
IL4 | P05112 | IL13RA1 | Homo sapiens | P78552 | 18243101 | |
|
Intra
|
IL4 | P05112 | IL4R | Homo sapiens | P24394 | 10219247 | |
|
Intra
|
IL4 | P05112 | IL4R | Homo sapiens | P24394 | 18243101 |
Recombinant IL4 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7042 | IL-4 Protein, Human (CHO) | P05112-1 (H25-S153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70445 | IL-4 Protein, Human | P05112-1 (H25-S153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70750 | IL-4 Protein, Human (HEK293) | P05112-1 (H25-S153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70764 | IL-4 Protein, Human (HEK293, His) | P05112-1 (H25-S153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70750G | GMP IL-4 Protein, Human (HEK293) | P05112-1 (H25-S153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P77510 | IL-4 Protein, Human (Biotinylated) | P05112-1 (H25-S153) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P78153 | IL-4 Protein, Human (Biotinylated, HEK293, His-Avi) | P05112-1 (H25-S153) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78466 | IL-4 Protein, Human (HEK293, His-Avi) | P05112-1 (H25-S153) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78549 | GMP IL-4 Protein, Human | P05112-1 (H25-S153) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700130AF | Animal-Free IL-4 Protein, Human (His) | P05112-1 (H25-S153) | ≥ 95%, as determined by reducing SDS-PAGE. |
IL4 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80722 | IL-4 Antibody (YA343) | WB | Human, Mouse, Rat |
| HY-P80722A | IL-4 Antibody (YA343)(PBS only) | WB | Human, Mouse, Rat |
| HY-P85017 | IL-4 Antibody (YA4709) | ELISA | Human |
| HY-P86669 | IL-4 Antibody (YA6361) | WB, IHC-P, IHC-F, IF-Tissue | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Scabies |
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| Amebiasis |
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| Laryngitis |
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| Meningitis |
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| Proteasome-Associated Autoinflammatory Syndrome 1 |
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| Mucocutaneous Leishmaniasis |
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| Chorioamnionitis |
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| B Cell Deficiency |
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| Toxoplasmosis |
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| Egg Allergy |
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| Thyroiditis |
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| Intrinsic Asthma |
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| Filariasis |
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| Fungal Infectious Disease |
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| Salivary Gland Disease |
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| Cystic Fibrosis |
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| Near-Fatal Asthma |
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| Papilloma |
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| Otitis Media |
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| Type 1 Diabetes Mellitus 8 |
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| Common Variable Immunodeficiency |
|
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| Allergic Rhinitis |
|
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| Hyper Ige Syndrome |
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| Gingival Disease |
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| Cryptococcal Meningitis |
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| Severe Combined Immunodeficiency, X-Linked |
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| Pneumonia |
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| Hypereosinophilic Syndrome |
|
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| Cercarial Dermatitis |
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| Upper Respiratory Tract Disease |
|
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| Mastocytosis |
|
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| Fascioliasis |
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| Stomatitis |
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| Primary Systemic Mycosis |
|
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| Mikulicz Disease |
|
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| Skin Atrophy |
|
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| Enterobiasis |
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| Thrombocytopenia |
|
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| Brucellosis |
|
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| Dermatitis Herpetiformis |
|
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| Burkitt Lymphoma |
|
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| Congenital Toxoplasmosis |
|
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| Erythema Multiforme |
|
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| Temporal Arteritis |
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| Silicosis |
|
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| Plasmacytoma |
|
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| Paracoccidioidomycosis |
|
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| Arthritis |
|
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| Immunoglobulin A Deficiency 1 |
|
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| Alveolar Echinococcosis |
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| Eosinophilic Gastroenteritis |
|
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| Autoimmune Disease Of Cardiovascular System |
|
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| Urinary Schistosomiasis |
|
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| Coronavirus Infectious Disease |
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| Bone Inflammation Disease |
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| Behcet Syndrome |
|
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| Nut Allergy |
|
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| Hashimoto Thyroiditis |
|
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| Schizophrenia |
|
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| Renal Cell Carcinoma, Nonpapillary |
|
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| Filarial Elephantiasis |
|
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| Uveal Disease |
|
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| Esophagitis, Eosinophilic, 1 |
|
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| Thunderstorm Triggered Asthma |
|
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| Vernal Keratoconjunctivitis |
|
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| Leukocyte Disease |
|
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| Asthma |
|
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| Autoimmune Disease Of Endocrine System |
|
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| Leukemia, Acute Myeloid |
|
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| Arteriosclerosis |
|
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| Blepharitis |
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| Mycobacterium Tuberculosis 1 |
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| Environmental Induced Asthma |
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| Chronic Mucocutaneous Candidiasis |
|
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| Yellow Fever |
|
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| Blau Syndrome |
|
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| Body Mass Index Quantitative Trait Locus 11 |
|
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| Eyelid Disease |
|
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| Keratoconjunctivitis |
|
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| Combined Immunodeficiency |
|
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| Lichen Disease |
|
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| Leishmaniasis |
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| Parasitic Protozoa Infectious Disease |
|
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| Q Fever |
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| Lacrimal Apparatus Disease |
|
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| Chronic Asthma |
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| Smallpox |
|
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| Malaria |
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| Graves' Disease |
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| Immune Deficiency Disease |
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| Potocki-Shaffer Syndrome |
|
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| Skin Disease |
|
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| Sezary'S Disease |
|
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| Periapical Granuloma |
|
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| Loiasis |
|
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| Lipoprotein Quantitative Trait Locus |
|
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| Candidiasis |
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| Neuritis |
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| Chronic Eosinophilic Pneumonia |
|
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| Uveitis |
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| Chromoblastomycosis |
|
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| Celiac Disease 1 |
|
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| Fruit Allergy |
|
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| Extrinsic Cardiomyopathy |
|
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| Pollen Allergy |
|
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| Pre-Eclampsia |
|
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| Autoimmune Disease Of Blood |
|
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| Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked |
|
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| Trypanosomiasis |
|
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| Tonsillitis |
|
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| Mycoplasma Pneumoniae Pneumonia |
|
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| Cystic Echinococcosis |
|
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| Tetanus |
|
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| Psoriasis |
|
|
| Aggressive Periodontitis |
|
|
| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
|
|
| Hypersensitivity Reaction Type Iv Disease |
|
|
| Exanthem |
|
|
| Myasthenia Gravis |
|
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| Hepatitis A |
|
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| Gastritis |
|
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| Neurodermatitis |
|
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| Miliary Tuberculosis |
|
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| Bronchiolitis |
|
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| Common Cold |
|
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| Osteomyelitis |
|
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| Chagas Disease |
|
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| Primary Biliary Cholangitis |
|
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| Parasitic Ectoparasitic Infectious Disease |
|
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| Gingivitis |
|
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| Multiple Sclerosis |
|
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| Endomyocardial Fibrosis |
|
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| Cryptococcosis |
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| Autoimmune Uveitis |
|
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| Osteoporosis |
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| Alopecia Areata |
|
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| Aspergillosis |
|
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| Middle Ear Disease |
|
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| Autoimmune Disease Of Skin And Connective Tissue |
|
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| Fungal Meningitis |
|
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| Drug Allergy |
|
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| Ulcerative Colitis |
|
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| Type 1 Diabetes Mellitus 7 |
|
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| Eczema Herpeticum |
|
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| T2-Low Asthma |
|
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| West Nile Encephalitis |
|
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| Lymphoid Interstitial Pneumonia |
|
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| Chronic Fatigue Syndrome |
|
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| Hypertension, Essential |
|
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| Autoimmune Disease Of Exocrine System |
|
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| Autoimmune Disease Of Eyes, Ear, Nose And Throat |
|
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| Hypothyroidism |
|
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| Alopecia |
|
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| B-Cell Growth Factor |
|
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| Glomerulonephritis |
|
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| Leukemia, Chronic Lymphocytic |
|
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| Herpangina |
|
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| Vernal Conjunctivitis |
|
|
| Chickenpox |
|
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| Dacryoadenitis |
|
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| Severe Combined Immunodeficiency |
|
|
| Primary Bacterial Infectious Disease |
|
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| Root Resorption |
|
|
| Inflammatory Bowel Disease 18 |
|
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| Ascaris Lumbricoides Infection |
|
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| Lymphopenia |
|
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| Nose Disease |
|
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| Immune System Disease |
|
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| Lichen Planus |
|
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| Paranasal Sinus Disease |
|
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| Toxocariasis |
|
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| Plague |
|
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| Neutropenia |
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| Irritant Dermatitis |
|
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| Opisthorchiasis |
|
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| Milk Allergy |
|
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| Allergic Disease |
|
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| Folliculitis |
|
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| Integumentary System Disease |
|
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| Adenoid Hypertrophy |
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| Conjunctival Disease |
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| Bronchial Disease |
|
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| Fibromyalgia |
|
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| Crohn'S Disease |
|
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| Autoimmune Disease Of Central Nervous System |
|
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| Neuromyelitis Optica |
|
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| Rhinitis |
|
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| Autoimmune Disease |
|
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| Ige Responsiveness, Atopic |
|
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| Colitis |
|
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| Viral Hepatitis |
|
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| Nasal Cavity Disease |
|
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| Disease By Infectious Agent |
|
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| Vasomotor Rhinitis |
|
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| Interstitial Lung Disease |
|
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| Diabetes Mellitus |
|
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| Respiratory Failure |
|
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| Bacterial Pneumonia |
|
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| Leptospirosis |
|
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| Familial Mediterranean Fever |
|
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| Dilated Cardiomyopathy |
|
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| Viral Infectious Disease |
|
|
| T2-High Asthma |
|
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| Breast Adenocarcinoma |
|
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| Autoimmune Myocarditis |
|
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| Chronic Rhinitis |
|
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| Diphtheria |
|
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| Parasitic Helminthiasis Infectious Disease |
|
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| Eye Disease |
|
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| Food Allergy |
|
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| Chondroblastoma |
|
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| Polycythemia Vera |
|
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| Chronic Spontaneous Urticaria |
|
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| Immunodeficiency With Hyper-Igm, Type 1 |
|
|
| Peripheral Nervous System Disease |
|
|
| Autoimmune Disease Of Musculoskeletal System |
|
|
| Major Depressive Disorder |
|
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| Conjunctivitis |
|
|
| Elephantiasis |
|
|
| Pulmonary Tuberculosis |
|
|
| Inflammatory Bowel Disease |
|
|
| Retinitis Pigmentosa 46 |
|
|
| Mycosis Fungoides |
|
|
| Melanoma |
|
|
| Pulmonary Eosinophilia |
|
|
| Periodontitis |
|
|
| Papillary Conjunctivitis |
|
|
| Dermatitis |
|
|
| Occupational Asthma |
|
|
| Pemphigoid |
|
|
| Acute Asthma |
|
|
| Human Immunodeficiency Virus Infectious Disease |
|
|
| Contact Dermatitis |
|
|
| Kimura Disease |
|
|
| Scleritis |
|
|
| Chronic Urticaria |
|
|
| Onchocerciasis |
|
|
| Strongyloidiasis |
|
|
| Tuberculoid Leprosy |
|
|
| Gastroesophageal Reflux |
|
|
| T Cell Deficiency |
|
|
| Colorectal Cancer |
|
|
| Legume Allergy |
|
|
| Trichinosis |
|
|
| Immunodeficiency With Hyper-Igm, Type 2 |
|
|
| Primary Progressive Multiple Sclerosis |
|
|
| Connective Tissue Disease |
|
|
| Chlamydia |
|
|
| Blepharoconjunctivitis |
|
|
| Cystitis |
|
|
| Chromium Allergic Contact Dermatitis |
|
|
| Type 1 Diabetes Mellitus |
|
|
| Covid-19 |
|
|
| Commensal Bacterial Infectious Disease |
|
|
| Cutaneous Leishmaniasis |
|
|
| Schistosomiasis |
|
|
| Irritable Bowel Syndrome |
|
|
| 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis |
|
|
| Allergic Asthma |
|
|
| Severe Acute Respiratory Syndrome |
|
|
| Cerebral Palsy |
|
|
| Spondyloarthropathy |
|
|
| Cholera |
|
|
| Giant Papillary Conjunctivitis |
|
|
| Urticaria |
|
|
| Rheumatoid Arthritis |
|
|
| Myocarditis |
|
|
| Severe Covid-19 |
|
|
| Peanut Allergy |
|
|
| Purpura |
|
|
| Allergic Bronchopulmonary Aspergillosis |
|
|
| Systemic Lupus Erythematosus |
|
|
| Splenic Disease |
|
|
| Pemphigus |
|
|
| Myeloma, Multiple |
|
|
| Cysticercosis |
|
|
| Demyelinating Disease |
|
|
| Rectal Disease |
|
|
| Cow Milk Allergy |
|
|
| Systemic Scleroderma |
|
|
| Coccidiosis |
|
|
| Igg4-Related Disease |
|
|
| Leprosy 3 |
|
|
| Alzheimer Disease 17 |
|
|
| Salmonellosis |
|
|
| Autoimmune Disease Of Gastrointestinal Tract |
|
|
| Mite Infestation |
|
|
| Bronchitis |
|
|
| Allergic Contact Dermatitis |
|
|
| Persistent Severe Asthma |
|
|
| Prostatitis |
|
|
| Nervous System Disease |
|
|
| Chronic Conjunctivitis |
|
|
| Lepromatous Leprosy |
|
|
| Esophagitis |
|
|
| Interstitial Lung Disease 2 |
|
|
| Agammaglobulinemia |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Nephrotic Syndrome |
|
|
| Respiratory Allergy |
|
|
| Keratoconjunctivitis Sicca |
|
|
| Rubella |
|
|
| Visceral Leishmaniasis |
|
|
| Intestinal Schistosomiasis |
|
|
| Taeniasis |
|
|
| Allergic Conjunctivitis |
|
|
| Respiratory System Disease |
|
|
| Gastroenteritis |
|
|
| Extrapulmonary Tuberculosis |
|
|
| Localized Scleroderma |
|
|
| Omenn Syndrome |
|
|
| Heart Disease |
|
|
| Cough Variant Asthma |
|
|
| Tick Infestation |
|
|
| Intermittent Asthma |
|
|
| Childhood-Onset Asthma |
|
|
| Trachoma |
|
|
| Dermatitis, Atopic |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Metal Allergy |
|
|
| Subacute Sclerosing Panencephalitis |
|
|
| Opportunistic Mycosis |
|
|
| Rheumatic Heart Disease |
|
|
| Exercise-Induced Bronchoconstriction |
|
|
| Eosinophilic Meningitis |
|
|
| Myocardial Infarction |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | IL4 | MGD | MGI:96556 |
| Canis familiaris | IL4 | VGNC | VGNC:41987 |
| Rattus norvegicus | IL4 | RGD | RGD:2898 |
| Felis catus | IL4 | VGNC | VGNC:67778 |
| Bos taurus | IL4 | VGNC | VGNC:30161 |
| Macaca mulatta | IL4 | VGNC | VGNC:73729 |
| Others | IL4 | NCBI |